The John Carroll University Institutional Animal Care and Use Committee (IACUC) is responsible for reviewing all research and teaching protocols involving the use of live vertebrate animals in order to ensure compliance with federal, state, and local regulations. The IACUC also conducts semiannual inspections of the John Carroll animal research program and facilities.

The role of the IACUC is to ensure that all animals used for teaching and research purposes are treated in a humane and sensitive manner and that no animals are used unnecessarily for these activities. The John Carroll University IACUC currently consists of nine members, including John Carroll and Cleveland State University faculty members, a veterinarian, a community member, and a non-scientist.