Expertise: Physiology, Endocrinology, Neuroscience
My major research interest is in the area of neuroscience. One thrust of the research is to examine circadian rhythms and the disruption of these rhythms in jet lag and shift work. Biotelemetry is the technique employed in our laboratory to monitor physiological and behavioral circadian rhythms in unrestrained, conscious animals. A second area of research interest concerns pathological states associated with addiction in rats. The study of the modulatory effects of the hormone, vasopressin, on physiological, biochemical, and behavioral processes in the mammalian organism is a third focus of my ongoing research. An experimental animal that is utilized to study these parameters is a rat genetically deficient in vasopressin (Brattleboro rat).
Murphy, H. M., Ihekoronze, C. and Wideman, C. H., Zolpidem-Induced Changes in Activity, Metabolism, and Anxiety in Rats, Pharmacology, Biochemistry and Behavior, 98, 81-86, 2011.
Wideman, C. H., and Murphy, H. M., Constant Light Induces Alterations in Melatonin Levels, Food Intake, Feed Efficiency, Visceral Adiposity, and Circadian Rhythms in Rats, Nutritional Neuroscience 12.5, 233-240, 2009.
Wideman, C. H., Nadzam, G. R., and Murphy, H. M., Implications of an Animal Model of Sugar Addiction, Withdrawal, and Relapse for Human Health, Nutritional Neuroscience 8, 269-276, 2005.
Murphy, H. M., Wideman, C. H., and Nadzam, G. R., A Laboratory Animal Model of Human Shift Work. Integrative Physiological and Behavioral Science 38, 316-328, 2003.
Murphy, H. M., Wideman, C. H., Aquila, L. A., and Nadzam, G. R. Telemetry Provides New Insight into Entrainment of Activity Wheel Circadian Rhythms and the Role of Body Temperature in the Activity-Stress Paradigm. Integrative Physiological & Behavioral Science, 37, 228-241, 2002.